【High Quality Material】- Surface is made of high quality PU leather, non-woven fabric inside. Stable structure and easy to clean. A stylish and practical way to store your tissu e and keep it close to hand, make your desk neat and organized
【High-end materials: 】 The surface is made of high-quality PU leather, Stable structure and easy to clean. A stylish and practical way to store your tissu es and keep it close to hand, make your desk neat and organized
【Mordern Design】- You can feel the touch of elegant with the leather finish; Square shape and leather surface is Modern, casual, functional and affordable design for the home or commercial use.
【Exquisite workmanship】:The tissue box holder is handmade.The bottom are waterproof and wear-resistant，lined with non-woven fabric which is easy to clean.
【Widely Used】- This leather tissu e box holders is the perfect cover for all standard cardboard tissu e boxes. It is nice for night stands, countertops, end tables, vanities and desks throughout your home; Use in kitchen, living room, bed room, bathroom, office
Features: Material: Surface is made of PU leather. Stable structure and easy to clean. A stylish and practical way to store your tissues and keep it close to hand, make your desk neat and organized. Modern Design: You can feel the touch of elegant with the PU leather finish. Square shape is modern, casual, functional and affordable design for the home or commercial use. Convenient to Use: Comes with a bottom cover to easily put the tissues into the tissue holder and a large opening for quick and easy access. Large Capacity: This tissue box cover can hold most standard-sized tissue as well as stacks of individual facial tissues. Works well in keeping the counter surface clutter free. Wide Use: It is nice for night stands, counter-tops, end tables, vanities and desks throughout your home. Use in kitchen, living room, bed room, bathroom, office.
Specification: Material: PU Leather Color: Black, White Size: About 13*13*13 cm/5.1*5.1*5.1 inch(L x W x H)
2020 Impact Factor: 9.941Submission > Acceptance: 52 days
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Transducin β-like protein 1 (TBL1) plays a crucial role in controlling the stability of regulatory proteins involved in cell proliferation and autophagy induction. This study revealed that, unlike normal B cells, diffuse large B-cell lymphoma cells express abundant levels of TBL1 and its overexpression correlates with poor clinical outcome. Targeting TBL1 promoted lymphoma cell death in vitro and in vivo. These results provide the rationale for targeting TBL1 as a novel therapeutic strategy in diffuse large B-cell lymphoma.
The authors of this study developed a single-chain antibody that targets a shear gradient-specific conformation of von Willebrnad factor (VWF). In vitro studies showed that this antibody specifically reduces VWF-GPIbα binding and thrombus formation at sites of shear rate gradients but does not block platelet deposition and aggregation under constant shear rate. This characteristic places the antibody in a new class of antiplatelet therapy for selective blockade of pathological thrombus formation while maintaining normal hemostasis.
A 26-year-old female developed vaccine-induced immune thrombotic thrombocytopenia (VITT) with cerebral venous thrombosis and bi-hemispheric hemorrhage following the first dose of the ChAdOx1 nCoV-19 vaccine. The treatment protocol, based on intravenous immunoglobulins, dexamethasone and argatroban was successful with almost complete clinical, laboratory and radiological response. This experience supports the application of an early and multidisciplinary therapeutic approach in cases of VITT, with the possibility of avoiding deaths and obtain a resolution of the syndrome.
This retrospective study compared the outcome of allogeneic hematopoietic stem cell transplantation (HSCT) in 23 patients with hematologic malignancies transplanted from non-sibling fully matched related donors to that of patients who underwent conventional haplo-HSCT. Subjects transplanted from fully matched related donors showed trends to a higher relapse rate and lower cumulative incidence of grade II-IV acute graft-versus-host disease, but overall survival was similar. The authors concluded that individualized adjustment of the immunosuppressive treatment is reasonable for this category of patients.